As expected, the realities of dual treatment are challenging.
“Forty-five percent of CKD stage 3–5 patients did not tolerate dual RAS blockade with 20 mg enalapril and 16 mg candesartan daily, primarily due to loss of renal function or hypotension.”
AJKD reports that Cinacelcet might be associated with leukocytoclastic vasculitis. Of course, the same can be said for just about any drug.
Cinacalcet-Induced Leukocytoclastic Vasculitis. [Am J Kidney Dis. 2009] – PubMed Result .
AJKD reports that Cinacelcet might be associated with leukocytoclastic vasculitis. Of course, the same can be said for just about any drug.
Cinacalcet-Induced Leukocytoclastic Vasculitis. [Am J Kidney Dis. 2009] – PubMed Result .
An FDA alert states that the anti-seizure medication zonisamide can cause a hyperchloremic (non-AG) metabolic acidosis. The risk increases with greater doses, but can occur with low-dose treatment. Younger patients and those with kidney disease may be at higher risk.
Information for Healthcare Professionals: Zonisamide marketed as Zonegran, and generics .
Several studies have looked for a link between anemia and now another study finds that 25-OH vitamin D levels below 20 ng/ml were associated with a marginally increased risk of anemia (OR 1.17, 95% CI 1.03-1.32) in pre-dialysis CKD. Statistically significant, but not all that impressive overall.
Not any chewing gum, but a gum with added phosphorous binder seems to have some promise. Take a look.