An FDA alert states that the anti-seizure medication zonisamide can cause a hyperchloremic (non-AG) metabolic acidosis. The risk increases with greater doses, but can occur with low-dose treatment. Younger patients and those with kidney disease may be at higher risk.
Information for Healthcare Professionals: Zonisamide marketed as Zonegran, and generics .
Carrying a pregnancy to term in patients undergoing hemodialysis can be a challenge. Yukari et al. in Kidney International find that lower BUN levels were associated with birth at a greater likelyhood of carrying pregnancy ? 32 weeks and a greater chance of birth weight ? 1.5kg. Although not the focus of the study, it appears that higher hemoglobins also correlated with improved likelihood of delivery.
Several studies have looked for a link between anemia and now another study finds that 25-OH vitamin D levels below 20 ng/ml were associated with a marginally increased risk of anemia (OR 1.17, 95% CI 1.03-1.32) in pre-dialysis CKD. Statistically significant, but not all that impressive overall.
Not any chewing gum, but a gum with added phosphorous binder seems to have some promise. Take a look.