Zonisamide (Zonegran) can cause metabolic acidosis
February 25th, 2009
An FDA alert states that the anti-seizure medication zonisamide can cause a hyperchloremic (non-AG) metabolic acidosis. The risk increases with greater doses, but can occur with low-dose treatment. Younger patients and those with kidney disease may be at higher risk.
Information for Healthcare Professionals: Zonisamide marketed as Zonegran, and generics .